Best sizing for 3bet?

The villain opening 22 from the UTG is pretty wide and aggressive, if you are going to raise you should do at least 3x the opening, but the size than him would fold 22 or any other two card than he would want to see a flop, just don't exist, even if you shove he may call you, him it's gonna call if he want's to, no matter how large you do it.

I'm playing 2NL for a short period of time and this is what I'm seeing on the tables, I may be wrong of course.

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You can open all PP from any position in 6 max. It is not too wide, or "maniac" style. But it is probably better to do it when you know you have a decent edge against the population so that you can play them profitably. Especially at NL2, where people don't 3bet enough (not even close to that).
I'm flating most of the times with AQo vs UTG. If you want to 3bet, make it bigger. Anything below 3x isn't going to make the difference most of the times because the price villain gets is still very good. Furthermore, he is at his strongest range in this scenario (UTG).

Betting 1/2 OTF is already too big for me on this board. Go 1/4. The reason is: your range is mostly value hands, so bet accordingly and force him to defend wider.
Turn bet size is not the best too imo. Bet bigger or check/back. You're playing 100bb effective, so make your life easier by betting bigger OTT and then shoving river (or check back IP depending on the card).
If you bet, for instance, 30bb, the river pot is going to be 105bb and UTG only has 55bb left. SPR is lower, which means your TPTK is better more often.
As played, you have to fold to the river shove. Your hand is never good here from my experience.

If you follow the charts at risk, you would raise any pocket pair and any As (A2s, A3s, A4s, A6s) from the EP, but are you really going to follow the charts at the NL2? because if you are playing the NL2 you usually don't have that edge.
I'm struggling to play because of that river calls, I like to think like this: If I have the better hand, the actions go by: I bet, they call. If they have the better hand: I bet, they raise/shove.

I'm not a good player but I'm trying to get there, I try to play more tight than the charts say, If you want to play a hand you raise at least 3x the OR, if you want to see a flop you just call IP, and if the villain give more action than the usually, you fold.

If you ask me I do not even consider playing a 22

You just answered with this hand why playing 22 from UTG is profitable at 2NL. Because you'll be paid too often when you hit a set. 3-b x2 makes absolutely no sence to me. AQo has about 50% equity vs standatd UTG open range, so you are not 3-b for value, or for protetion, or for initiative, he will never fold for 3 whatever he has and you are OOP for the rest of the hand. You should either just call and that's what I would do, or 3-b big to at least 10 so you will gain a real initiative and you'll take the pot pre some of the time.
I don't like postflop sizings too and you should absolutely fold OTR, this is just never bluff, you'll lose close to 100% of the time.

55 and above im raising from any position on 6max. Under that it depends on position

People ... you are not taking into account the cost of the rake to call. It is more profitable to play a 3-B Fold strategy due to rake.
For me the optimal thing would be to make a 3bet longer (x4, x5) if we know that the player tends to call more so we get that his call is incorrect and with position try to realize our equity.
(pot control, bet sizes, etc)

Originally posted by GiaconeL
People ... you are not taking into account the cost of the rake to call. It is more profitable to play a 3-B Fold strategy due to rake.
For me the optimal thing would be to make a 3bet longer (x4, x5) if we know that the player tends to call more so we get that his call is incorrect and with position try to realize our equity.
(pot control, bet sizes, etc)

I enjoy SplitSuit's YouTube videos. I understood that a 3 to 4 times 3 bet was standard. Overall, SplitSuit's approach is too aggressive for me. But, I like 3x to 4x, 3bet. I am a bit concerned that a 5x, 3 bet would chase away action that I want. However, I am commenting to your "not taking into account the cost of the rake" statement. Darn! You are much smarter than I am! I never even considered being so precise that I can consider Rake in poker decisions. That is way above my current playing level. Maybe, in five years if I develop pro skills, I might include that metric.

People ... you are not taking into account the cost of the rake to call. It is more profitable to play a 3-B Fold strategy due to rake.

I do not agree. This is 2NL and we are much better players than the field and most of our edge comes postflop. Much more and much costly mistakes are made postflop than preflop. I want to be involved in as many postflop spots as possible to realize my edge. The rake of 3.5% is just about nothing. At 10 or 25NL you are right we should try to win more pots pre, but not here.

AQo is this 3bet for value or for a bluff? It is call,imo.
You give him good odd to call, 3bet standard 3X...
You lose because call river all-in, it is clear fold,imo.

AQ is a standard 3bet. Your sizing is off, 8-9BB IP should be good.
I think your play is fine. Sizing is decent, perhaps a little more on the turn. I don't mind the thin value bet on the river but you have to fold if you get shoved on.