Just for the sake of completeness...
You can raise the flop whenever your equity is greater than the average equity.
So, for example, with the nut flush draw your equity is ~35%.
The average equity = 100/number of players in the hand.
So:
2 handed average equity = 50%
3 handed average equity = 33.3%
4 handed average equity = 25%, etc.
In this example we are 5 handed in a pot that got capped pre flop and the pre flop aggressors have both entered the pot. A raise is therefore pretty safe as you will likely have at least 2 other players call the raise. As 35% > 33.3% you can raise.
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BTW, I suspect the river 3 bet is overplayed, you are in a four handed pot and I would guess you are behind too many hands to have the equity for a 3 bet here (ie TT, JTs, 44, 22).










