I find that if I play in succession I tend to wear down after about 25 games.
I can play on but it won't be optimal play and as mentioned bathroom breaks are a must.
I usually hit the same amount of games in a day either by playing in succesion for 25 at a time
and taking a 5 to 10 min break and then playing 25 more 12 tabling or by doing it in sets of 12.
Sets of 12 may take longer but energy wise or for optimal play it works out to be the same for me.
Once I become an advanced player I am sure there will be a huge difference in volume between
the two methods but for now I would not recommend playing more than you can handle
and challenge yourself to increase your volume as you become very comfortable with your
current level of games / play.
If you have table ninja you can try setting it to open games continuously for say 1 hour at first
and try a smaller amount of games like 6 at once to see if you can handle the different blind levels.
Also... You can open a set up and when you have only a few tables left at higher blind levels
you can start opening up more games and they will be taking less of your attention because
at lower blind levels your play is much more static and decisions are easier. This allows for more
focus on the tables at the end game stages.
I highly recommend table ninja for this as you can let it auto open more games and keep
your attention on the high blind tables. This does limit your choice of sites but there are
AHK scripts for others which I am unfamiliar with.
I am a fan of stacking so far up to the $6.50s. I do know I will probably have to change to tiled
at higher limits but for practice with late game decisions and for not watching the board play out
and get affected by bad runs instead of applauding good decisions I recommend it for micro level
games if not cascaded and with both methods pulling tables out to an unused part of the monitor
as needed. In order to avoid getting tired I have my tables set to a small size with optimal font
(On stars it adjusts as you adjust the screen) So I am focused on a small area and can see all
my stats and stack sizes etc without moving my eyes very much. This leaves plenty of room
for moving tables out of the cascade / stack to concentrate on if needed.
My second screen is used for the lobby and finding multi tablers / table selection as my set fires up.
I use HEM stats to keep track of regs and I watch who is playing at me and who is too tight.
It takes a while to get the hang of but you can keep up when playing 12 games of who the regs
are and get good reads. Once you adjust to most solid regs they back off but some do not
realize and keep playing without adjusting to your adjustment.
There i a good silver video by J little on multi tabling in the strategy section that I found helpful.
And as was mentioned about final tables appearing different....
Some sites have empty seats on non final tables and on final tables as players are eliminated
the seat itself dissapears so you can tell when you are on a final table that way.
I am still a fish but the above works well for me.