* Please try updating to the latest version 1.11.05e http://www.holdemmanager.com/Downloads/HmUpdate.exe
* Under Vista and Windows 7 make sure that holdemmanager.exe, hmhud.exe and dbcontrolpanel.exe are started as administrator. Run the windows explorer and navigate to your Holdemmanager installation directory. Right click the holdemmanager.exe, dbcontrolpanel.exe and the hmhud.exe executable and select "Run as admin" from the popup menu under compatibilty.
* If that doesn't help, please check this and answer and post the questions http://faq.holdemmanager.com/questions/48/My+HUD+Doesn 't+Work
For the positions:
configure the preferred seating of your Pokerclient and the seating preferences in HM accordingly
* open one Table, play at least one hand
* move the stats with the right mouse key to the correct positions
* Table manager -> Table -> Save positions
* Now you can open further tables but you will always have to play at least one hand for the stats being moved to the correct positions.
See our preferred seating FAQ:
http://faq.holdemmanager.com/questions/34/Preferred+Seating