It should be noted that the Omaha version reveals the flop before the players make their decisions, while the Hold'em version is played entirely preflop.
The low stack to blinds ratio deserves special attention, making successful blind steals alone quite profitable. This should definitely be taken into account when anyone tries to develop a strategy for this format. Tightening up and waiting for premium hands just won't do, and coming up with a good plan for blinds defense is a necessity.
As mpranjic pointed out, ratholing is allowed in this game, possibly even encouraged. There is an easily available option to move any excess chips back to your balance at any time, so you won't have to worry about risky deep stack clashes if you choose so.
I have only played the Omaha version so far, and while there does seem to be a lot of potential for a decent edge, I personally found these games to be mostly rake traps. I believe there is some mandatory "big hand jackpot" which also takes a lot of chips per hand, and I don't know the exact math, but the rake (including jackpot payments) really is quite considerable, and tough to overcome in my experience.
So I'd urge caution to any newcomers rushing in. The games may be beatable, but I believe they can look a lot more profitable at first glance than they actually are. If anyone can make a more in-depth analysis of them, I'd be interested as well.