calling 5bb open on the BTN with 65s

Pre isn't bad. Vs 3x it would be a standard call, vs 5x you could consider folding but still not bad to call imo.

I think that river sizing is unnecessary. PSB or maybe even under that will work almost as often. Your sizing might even look bluffy to some players and you would get more calls than you would with 80% bet.

You can fold pre. The blinds seem active and vs a bigger open you do not have to defend that wide.
There are possible better hands so I prefer betting smaller OTR.

I don't hate the river sizing in general but you might want to try something smaller vs. this opponent. Realistically, your overall value range should be fairly tight here- you don't have many 4x and obviously 88/33 are there. Vs. a donk, I like your sizing, but vs. this opponent, maybe a smaller size is better. Either way, I don't know if villain is folding an overpair vs. any sizing, so not quite sure.

Close. I'd probably call 4 bb, but fold to 5 bb. It's a matter of stack sizes. If he also had 300 bb, then it would be a super trivial call. Now he has 110, and the blinds do seem a bit angry as nitrol notes.